Laboratory of Growth Regulators
Laboratory of Growth Regulators has been created in 1995 as a joined facility of the Faculty of Science, Palacký University (www.upol.cz) and the Institute of Experimental Botany of the Czech Academy of Sciences (www.ueb.cas.cz).
Research program of the laboratory is aimed primary at small molecules that regulate cell division cycle, proliferation and growth of both plant and animal cells. Namely cytokinins and cytokinin-derived purine inhibitors of cyclin-dependent kinases belongs to the most intensively studied compounds. The representative of the latter, roscovitine (CYC202, seliciclib), already undergoes phase II clinical trials in patients as a novel anticancer drug held by Cyclacel Ltd (for more information see actual Press Release).
Our multidisciplinary research team is composed of experienced plant physiologists, biochemists as well as organic and analytical chemists. Many students are involved in the research during their pregradual and postgraduate studies of botany, analytical and organic chemistry, biochemistry or medicinal biology, respectively.
Laboratory of Growth Regulators guarantees the teaching for biological study programs. Members of the laboratory give lectures from general botany, plant physiology, microbiology, chemistry, molecular biology, including practical courses and seminars.
Several reseach projects are in progress in colaboration with international partners (University of Berlin, Germany; Swedish University of Agricultural Sciences, Sweden; University of Natal Pietermaritzburg, South Africa; Vienna Medical University, Austria).
head of the laboratorysenior scientist
- Prof. ing. Miroslav Strnad CSc.
graduated technical assistant
- Jitka Hansgutová DiS.
- BIOORGANIC AND MEDICAL CHEMISTRY LETTERS 13  2989-2992 2003
- BIOORGANIC AND MEDICAL CHEMISTRY LETTERS 13  2993-2996 2003
Effect of postharvest period on sugars, organic acids and fatty acids composition in commercially sold medlar (Mespilus germanica 'Dutch') fruitEUROPEAN FOOD RESEARCH AND TECHNOLOGY 216  390-394 2003
- FEBS LETTERS 533 [1/3] 63-66 2003
Changes in sugars, organic acids and amino acids in medlar (Mespilus germanica L.) during fruit development and maturationFOOD CHEMISTRY 83  363-369 2003
Mixed ligand complexes of platinum(II) and palladium(II) with cytokinin-derived compounds Bohemine and Olomoucine: X-ray structure of [Pt(BohH+-N7)Cl(3)].9/5H2O [Boh=6-(benzylamino)-2-[(3-(hydroxypropyl)-amino]-9-isopropylpurine, Bohemine]JOURNAL OF INORGANIC BIOCHEMISTRY 94  307-316 2003
Identification of new aromatic cytokinins in Arabidopsis thaliana and Populus x canadensis leaves by LC-(+)ESI-MS and capillary liquid chromatography/frit-fast atom bombardment mass spectrometryPHYSIOLOGIA PLANTARUM 117  579-590 2003
- PLANT GROWTH REGULATION 39  205-215 2003
A simple brassinolide analogue 2ŕ, 3ŕ-dihydroxy-17á-(3-methyl-butyryloxy)-7-oxa-B-homo-5ŕ-androstan-6-one which induces bean second internode splittingPLANT GROWTH REGULATION 40 39-47 2003
- PLANT GROWTH REGULATION 41  13-24 2003