A Mitogen-activated protein kinase kinase kinase mediates reactive oxygen species homeostasis in Arabidopsis

Nakagami, H.; Soukupová, Hana; Schikora, A.; Žárský, Viktor; Hirt, H.
JOURNAL OF BIOLOGICAL CHEMISTRY 281 [50]: 38697-38704, 2006

Keywords: OXIDATIVE STRESS; MAP; PATHWAYS
Abstract: Mitogen-activated protein kinase kinase kinases (MAPKKK) play key roles in intra- and extracellular signaling in eukaryotes. MAPKKK MEKK1 regulates redox homeostasis in Arabidopsis. MEKK1-deficient plants are misregulated in the expression of a number of genes involved in cellular redox control and accumulate reactive oxygen species (ROS). mekk1 mutant plants exhibit a lethal phenotype when developing true leaves. In agreement with the concept that ROS negatively regulates auxin responses in plants, mekk1 mutants show reduced expression of several auxin-inducible marker genes.
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IEB authors: Viktor Žárský