Čeština
EnglishIn vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb.
Landa P., Skalova L., Bousova I., Kutil Z., Langhansova L., Lou J.-D., Vanek T.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES 27[1]: 103-106, 2014
Keywords: anti-proliferative activity, anti-inflammatory activity, breast cancer, cyclooxygenase, Vaccinium bracteatum, xCELLigence system
Abstract: The aim of this study was to evaluate in vitro anti-proliferative (tested on MCF-7, MDA-MB-231, and MCF-10A cell lines) and anti-inflammatory (evaluated as inhibition of prostaglandin E2 synthesis catalyzed by cyclooxygenase-2) effect of various extracts from Vaccinium bracteatum leaves and fruits. The highest anti-proliferative effect possessed leaf dichloromethane extract with IC50 values ranging from 93 to 198 μg/mL. In the case of cyclooxygenase-2 inhibition, n-hexane, dichloromethane, and ethanol fruit extracts showed the best activity with IC50 values = 2.0, 5.4, and 12.7 μg/mL, respectively. These results indicate that V. bracteatum leaves and fruits could be useful source of anti-cancer and anti-inflammatory compounds.
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IEB authors: Přemysl Landa, Lenka Langhansová, Tomáš Vaněk, bývalý zaměstnanec
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES 27[1]: 103-106, 2014
Keywords: anti-proliferative activity, anti-inflammatory activity, breast cancer, cyclooxygenase, Vaccinium bracteatum, xCELLigence system
Abstract: The aim of this study was to evaluate in vitro anti-proliferative (tested on MCF-7, MDA-MB-231, and MCF-10A cell lines) and anti-inflammatory (evaluated as inhibition of prostaglandin E2 synthesis catalyzed by cyclooxygenase-2) effect of various extracts from Vaccinium bracteatum leaves and fruits. The highest anti-proliferative effect possessed leaf dichloromethane extract with IC50 values ranging from 93 to 198 μg/mL. In the case of cyclooxygenase-2 inhibition, n-hexane, dichloromethane, and ethanol fruit extracts showed the best activity with IC50 values = 2.0, 5.4, and 12.7 μg/mL, respectively. These results indicate that V. bracteatum leaves and fruits could be useful source of anti-cancer and anti-inflammatory compounds.
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