Laboratory of Growth Regulators
Laboratory of Growth Regulators has been created in 1995 as a joined facility of the Faculty of Science, Palacký University (www.upol.cz) and the Institute of Experimental Botany of the Czech Academy of Sciences (www.ueb.cas.cz).
Research program of the laboratory is aimed primary at small molecules that regulate cell division cycle, proliferation and growth of both plant and animal cells. Namely cytokinins and cytokinin-derived purine inhibitors of cyclin-dependent kinases belongs to the most intensively studied compounds. The representative of the latter, roscovitine (CYC202, seliciclib), already undergoes phase II clinical trials in patients as a novel anticancer drug held by Cyclacel Ltd (for more information see actual Press Release).
Our multidisciplinary research team is composed of experienced plant physiologists, biochemists as well as organic and analytical chemists. Many students are involved in the research during their pregradual and postgraduate studies of botany, analytical and organic chemistry, biochemistry or medicinal biology, respectively.
Laboratory of Growth Regulators guarantees the teaching for biological study programs. Members of the laboratory give lectures from general botany, plant physiology, microbiology, chemistry, molecular biology, including practical courses and seminars.
Several reseach projects are in progress in colaboration with international partners (University of Berlin, Germany; Swedish University of Agricultural Sciences, Sweden; University of Natal Pietermaritzburg, South Africa; Vienna Medical University, Austria).
head of the laboratorysenior scientist
- Prof. ing. Miroslav Strnad CSc.
graduated technical assistant
- Jitka Hansgutová DiS.
Electrical and chemical signals involved in short-term systemic photosynthetic responses of tobacco plants to local burningPLANTA 225 235-244 2006
- POLISH JOURNAL OF CHEMISTRY 80  629-635 2006
Kinetic and chemical analyses of the cytokinin dehydrogenase-catalysed reaction: correlations with the crystal structureBIOCHEMICAL JOURNAL 398  113-124 2006 Fulltext: public PDF link
Development of erect leaves in a modern maize hybrid is associated with reduced responsiveness to auxin and light of young seedlings in vitroPLANT SIGNALLING & BEHAVIOR 1 201-211 2006
- BIOLOGIA PLANTARUM 50  465-468 2006
- ZEITSCHRIFT FUER NATURFORSCHUNG. SECTION C: A JOURNAL OF BIOSCIENCES 61 [5-6] 387-396 2006
- BIOMEDICAL PAPERS 149  349-351 2005
- BIOORGANIC AND MEDICAL CHEMISTRY 13  5399-5407 2005
Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cellsBIOORGANIC AND MEDICAL CHEMISTRY 14  875-884 2005
- In 21st Conference on Isoprenoids. Bialystok : University of Bialystok (2005) 30 2005