Laboratory of Growth Regulators
Laboratory of Growth Regulators has been created in 1995 as a joined facility of the Faculty of Science, Palacký University (www.upol.cz) and the Institute of Experimental Botany of the Czech Academy of Sciences (www.ueb.cas.cz).
Research program of the laboratory is aimed primary at small molecules that regulate cell division cycle, proliferation and growth of both plant and animal cells. Namely cytokinins and cytokinin-derived purine inhibitors of cyclin-dependent kinases belongs to the most intensively studied compounds. The representative of the latter, roscovitine (CYC202, seliciclib), already undergoes phase II clinical trials in patients as a novel anticancer drug held by Cyclacel Ltd (for more information see actual Press Release).
Our multidisciplinary research team is composed of experienced plant physiologists, biochemists as well as organic and analytical chemists. Many students are involved in the research during their pregradual and postgraduate studies of botany, analytical and organic chemistry, biochemistry or medicinal biology, respectively.
Laboratory of Growth Regulators guarantees the teaching for biological study programs. Members of the laboratory give lectures from general botany, plant physiology, microbiology, chemistry, molecular biology, including practical courses and seminars.
Several reseach projects are in progress in colaboration with international partners (University of Berlin, Germany; Swedish University of Agricultural Sciences, Sweden; University of Natal Pietermaritzburg, South Africa; Vienna Medical University, Austria).
head of the laboratorysenior scientist
- Prof. ing. Miroslav Strnad CSc.
graduated technical assistant
- Jitka Hansgutová DiS.
Changes in cytokinin and auxin concentrations in seaweed concentrates when stored at an elevated temperatureJOURNAL OF PHYCOLOGY 16  31-39 2004
- JOURNAL OF PHYCOLOGY 40  88-95 2004
Synergic effects of the cyclin-dependent kinase (CDK) inhibitor olomoucine and androgen-antagonist bicalutamide on prostatic cancer cell linesNEOPLASMA 51  358-367 2004
Cytokinin N-glucosylation inhibitors suppress deactivation of exogenous cytokinins in radish, but their effect on active endogenous cytokinins is counteracted by other regulatory mechanismsPHYSIOLOGIA PLANTARUM 121  215-222 2004
Two Cytokinin Receptors of Arabidopsis thaliana, CRE1/AHK4 and AHK3, Differ in their Ligand Specificity in a Bacterial AssayPLANT AND CELL PHYSIOLOGY 45  1299-1305 2004
- BIOCHEMICAL JOURNAL 380  121-130 2004
Derivatization for LC-Electrospray Ionization-MS: A Tool for Improving Reversed-Phase Separation and ESI Responses of Bases, Ribosides, and Intact NucleotidesANALYTICAL CHEMISTRY 76  2869-2877 2004
Auxin regulation of cytokinin biosynthesis in Arabidopsis thaliana: A factor of potential importance for auxin-cytokinin-regulated developmentPNAS 101  8039-8044 2004
- ZEITSCHRIFT FUER NATURFORSCHUNG. SECTION C: A JOURNAL OF BIOSCIENCES 59 [9/10] 673-678 2004
Quantitative analysis of cytokinins in plants by liquid chromatography single-quadrupole mass spectrometryANALYTICA CHIMICA ACTA 480  207-218 2003