Laboratory of Growth Regulators
Laboratory of Growth Regulators has been created in 1995 as a joined facility of the Faculty of Science, Palacký University (www.upol.cz) and Institute of Experimental Botany, Academy of Sciences of the Czech Republic (www.ueb.cas.cz).
Research program of the laboratory is aimed primary at small molecules that regulate cell division cycle, proliferation and growth of both plant and animal cells. Namely cytokinins and cytokinin-derived purine inhibitors of cyclin-dependent kinases belongs to the most intensively studied compounds. The representative of the latter, roscovitine (CYC202, seliciclib), already undergoes phase II clinical trials in patients as a novel anticancer drug held by Cyclacel Ltd (for more information see actual Press Release).
Our multidisciplinary research team is composed of experienced plant physiologists, biochemists as well as organic and analytical chemists. Many students are involved in the research during their pregradual and postgraduate studies of botany, analytical and organic chemistry, biochemistry or medicinal biology, respectively.
Laboratory of Growth Regulators guarantees the teaching for biological study programs. Members of the laboratory give lectures from general botany, plant physiology, microbiology, chemistry, molecular biology, including practical courses and seminars.
Several reseach projects are in progress in colaboration with international partners (University of Berlin, Germany; Swedish University of Agricultural Sciences, Sweden; University of Natal Pietermaritzburg, South Africa; Vienna Medical University, Austria).
head of the laboratorysenior scientist
- Prof. ing. Miroslav Strnad CSc.
- RNDr. Martin Fellner Ph.D.
- Jiří Grúz
- Doc., Ing. Jan Krekule DrSc.
- Doc. RNDr. Vladimír Kryštof Ph.D.
- RNDr. Miroslav Kvasnica Ph.D.
- Mgr. Ondřej Novák Ph.D.
- Ing. Ludmila Ohnoutková Ph.D.
- Mgr. Jana Oklešťková PhD.
- Mgr. Lucie Plíhalová Ph.D.
- Jiří Pospíšil
- Jitka Široká
- Mgr. Danuše Tarkowská Ph.D.
- Jiří Voller
graduated technical assistant
- Jitka Hansgutová DiS.
Immunoaffinity chromatography combined with tandem mass spectrometry: a new tool for the selective capture and analysis of brassinosteroid plant hormonesTALANTA 170 432-440 2017 (External fulltext)
Quantitative analysis of ingenol in Euphorbia species via validated isotope dilution ultra-high performance liquid chromatography-tandem mass spectrometryPHYTOCHEMICAL ANALYSIS 2017
- PLANT PHYSIOLOGY 173 552-565 2017 (External fulltext)
- ANNALS OF BOTANY 119 151-166 2017 Fulltext: PDF link on intranet only
- PLANT PHYSIOLOGY 174 1260-1273 2017 (External fulltext)
- JOURNAL OF PLANT PHYSIOLOGY 214 53-63 2017 (External fulltext)
The DAG1 transcription factor negatively regulates the seed-to-seedling transition in Arabidopsis acting on ABA and GA levelsBMC PLANT BIOLOGY 16 198 2016 (External fulltext)
A previously undescribed jasmonate compound in flowering Arabidopsis thaliana - The identification of cis-(+)-OPDA-IlePHYTOCHEMISTRY 230-237 2016 (External fulltext)
5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases Record contains structuresEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 110 291-301 2016 Fulltext: public PDF link
The determination of 22 natural brassinosteroids in a minute sample of plant tissue by UHPLC–ESI–MS/MSANALYTICAL AND BIOANALYTICAL CHEMISTRY 2016 (External fulltext)