Laboratory of Growth Regulators
Laboratory of Growth Regulators has been created in 1995 as a joined facility of the Faculty of Science, Palacký University (www.upol.cz) and the Institute of Experimental Botany of the Czech Academy of Sciences (www.ueb.cas.cz).
Research program of the laboratory is aimed primary at small molecules that regulate cell division cycle, proliferation and growth of both plant and animal cells. Namely cytokinins and cytokinin-derived purine inhibitors of cyclin-dependent kinases belongs to the most intensively studied compounds. The representative of the latter, roscovitine (CYC202, seliciclib), already undergoes phase II clinical trials in patients as a novel anticancer drug held by Cyclacel Ltd (for more information see actual Press Release).
Our multidisciplinary research team is composed of experienced plant physiologists, biochemists as well as organic and analytical chemists. Many students are involved in the research during their pregradual and postgraduate studies of botany, analytical and organic chemistry, biochemistry or medicinal biology, respectively.
Laboratory of Growth Regulators guarantees the teaching for biological study programs. Members of the laboratory give lectures from general botany, plant physiology, microbiology, chemistry, molecular biology, including practical courses and seminars.
Several reseach projects are in progress in colaboration with international partners (University of Berlin, Germany; Swedish University of Agricultural Sciences, Sweden; University of Natal Pietermaritzburg, South Africa; Vienna Medical University, Austria).
head of the laboratorysenior scientist
- doc. Mgr. Ondřej Novák Ph.D.
deputy head of the laboratoryscientist
- Prof. ing. Miroslav Strnad CSc.
graduated technical assistant
The effects of exogenous salicylic acid on endogenous phytohormone status in Hordeum vulgare L. under salt stressPLANTS 11 618 2022 (External fulltext)
- PLANT CELL AND ENVIRONMENT 45 1315-1332 2022 (External fulltext)
The phytotoxin myrigalone A triggers a phased detoxification programme and inhibits Lepidium sativum seed germination via multiple mechanisms including interference with auxin homeostasisINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 4618 2022 (External fulltext)
- DEVELOPMENTAL CELL 2022 (External fulltext)
- PLANTS 11 313 2022 (External fulltext)
A mitochondrial ADXR-ADX-P450 electron transport chain is essential for maternal gametophytic control of embryogenesis in ArabidopsisPROCEEDINGS OF THE NAS OF THE USA 119 e2000482119 2022 (External fulltext)
Salt-specific gene expression reveals elevated auxin levels in Arabidopsis thaliana plants grown under saline conditionsFRONTIERS IN PLANT SCIENCE 13 804716 2022 (External fulltext)
The photoperiod stress response in Arabidopsis thaliana depends on auxin acting as an antagonist to the protectant cytokininINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 2936 2022 (External fulltext)
- FRONTIERS IN PLANT SCIENCE 13 844292 2022 (External fulltext)