Laboratory of Growth Regulators
Laboratory of Growth Regulators has been created in 1995 as a joined facility of the Faculty of Science, Palacký University (www.upol.cz) and the Institute of Experimental Botany of the Czech Academy of Sciences (www.ueb.cas.cz).
Research program of the laboratory is aimed primary at small molecules that regulate cell division cycle, proliferation and growth of both plant and animal cells. Namely cytokinins and cytokinin-derived purine inhibitors of cyclin-dependent kinases belongs to the most intensively studied compounds. The representative of the latter, roscovitine (CYC202, seliciclib), already undergoes phase II clinical trials in patients as a novel anticancer drug held by Cyclacel Ltd (for more information see actual Press Release).
Our multidisciplinary research team is composed of experienced plant physiologists, biochemists as well as organic and analytical chemists. Many students are involved in the research during their pregradual and postgraduate studies of botany, analytical and organic chemistry, biochemistry or medicinal biology, respectively.
Laboratory of Growth Regulators guarantees the teaching for biological study programs. Members of the laboratory give lectures from general botany, plant physiology, microbiology, chemistry, molecular biology, including practical courses and seminars.
Several reseach projects are in progress in colaboration with international partners (University of Berlin, Germany; Swedish University of Agricultural Sciences, Sweden; University of Natal Pietermaritzburg, South Africa; Vienna Medical University, Austria).
head of the laboratorysenior scientist
- Prof. ing. Miroslav Strnad CSc.
graduated technical assistant
- Jitka Hansgutová DiS.
- PROCEEDINGS OF THE NAS OF THE USA 2019 (External fulltext)
Mutations in the HvDWARF, HvCPD and HvBRI1 genes – involved in brassinosteroid biosynthesis/signalling – altered photosynthetic efficiency, hormonal homeostasis and tolerance to high/low temperatures in barley.JOURNAL OF PLANT GROWTH REGULATION 2019
Changes in content of steroid regulators during cold hardening of winter wheat - Steroid physiological/biochemical activity and impact on frost resistancePLANT PHYSIOLOGY AND BIOCHEMISTRY 2019
- CURRENT BIOLOGY 29 2743-2750.e5 2019 (External fulltext)
Endogenous hypoxia in lateral root primordia controls root architecture by antagonizing auxin signaling in ArabidopsisMOLECULAR PLANT 12 538-551 2019 (External fulltext)
- NATURE COMMUNICATIONS 10 3540 2019 (External fulltext)
A role for the auxin precursor anthranilic acid in root gravitropism via regulation of PIN-FORMED protein polarity and relocalisation in ArabidopsisNEW PHYTOLOGIST 223 1420–1432 2019 (External fulltext)
- PROCEEDINGS OF THE NAS OF THE USA 116 6463-6472 2019 (External fulltext)
A molecular framework for the control of adventitious rooting by the TIR1/AFB-Aux/IAA-dependent auxin sensing in ArabidopsisMOLECULAR PLANT 12 1499-1514 2019 (External fulltext)
Multifaceted activity of cytokinin in leaf development shapes its size and structure in Arabidopsis.PLANT JOURNAL 97 805–824 2019 (External fulltext)