Laboratory of Growth Regulators
Laboratory of Growth Regulators has been created in 1995 as a joined facility of the Faculty of Science, Palacký University (www.upol.cz) and the Institute of Experimental Botany of the Czech Academy of Sciences (www.ueb.cas.cz).
Research program of the laboratory is aimed primary at small molecules that regulate cell division cycle, proliferation and growth of both plant and animal cells. Namely cytokinins and cytokinin-derived purine inhibitors of cyclin-dependent kinases belongs to the most intensively studied compounds. The representative of the latter, roscovitine (CYC202, seliciclib), already undergoes phase II clinical trials in patients as a novel anticancer drug held by Cyclacel Ltd (for more information see actual Press Release).
Our multidisciplinary research team is composed of experienced plant physiologists, biochemists as well as organic and analytical chemists. Many students are involved in the research during their pregradual and postgraduate studies of botany, analytical and organic chemistry, biochemistry or medicinal biology, respectively.
Laboratory of Growth Regulators guarantees the teaching for biological study programs. Members of the laboratory give lectures from general botany, plant physiology, microbiology, chemistry, molecular biology, including practical courses and seminars.
Several reseach projects are in progress in colaboration with international partners (University of Berlin, Germany; Swedish University of Agricultural Sciences, Sweden; University of Natal Pietermaritzburg, South Africa; Vienna Medical University, Austria).
head of the laboratorysenior scientist
- doc. Mgr. Ondřej Novák Ph.D.
deputy head of the laboratoryscientist
- Prof. ing. Miroslav Strnad CSc.
Synthesis and Biological Activity of Brassinosteroid Analogues with a Nitrogen-Containing Side ChainINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22 155 2021
Molecular Dynamics of Chloroplast Membranes Isolated from Wild-Type Barley and a Brassinosteroid-Deficient Mutant Acclimated to Low and High TemperaturesBIOMOLECULES 11 27 2021
Insight into Details of the Photosynthetic Light Reactions and Selected Metabolic Changes in Tomato Seedlings Growing under Various Light SpectraINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22 2021
Molecular mechanisms of plant steroids and study of their interaction with nuclear receptors in prostate cancer cellsFOOD AND CHEMICAL TOXICOLOGY 137 2020
- FRONTIERS IN PLANT SCIENCE 11 736 2020 (External fulltext)
Plant Triterpenoid Crosstalk: The Interaction of Brassinosteroids and Phytoecdysteroids in Lepidium sativumPLANTS 9 1325 2020 (External fulltext)
Exogenous gibberellin complements for the functions of the Arabidopsis RLCK VI_A2 kinase during seedling and plant growthINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21 7266 2020 (External fulltext)
The Response of Maize to Inoculation with Arthrobacter sp. and Bacillus sp. in Phosphorus-Deficient, Salinity-Affected SoilMICROORGANISMS Microorganisms 8 1005 2020 (External fulltext)
A Fast and Reliable UHPLC–MS/MS-Based Method for Screening Selected Pharmacologically Significant Natural Plant Indole AlkaloidsMOLECULES 25 3274 2020 (External fulltext)
Phytohormone profile and CiFL1 expression in young seedlings of Cichorium intybus L. var sativum exposed to high temperature in relation to vernalization and de-vernalization processesENVIRONMENTAL AND EXPERIMENTAL BOTANY 178 104127 2020 Fulltext: PDF link on intranet only