Laboratory of Growth Regulators
Laboratory of Growth Regulators has been created in 1995 as a joined facility of the Faculty of Science, Palacký University (www.upol.cz) and Institute of Experimental Botany, Academy of Sciences of the Czech Republic (www.ueb.cas.cz).
Research program of the laboratory is aimed primary at small molecules that regulate cell division cycle, proliferation and growth of both plant and animal cells. Namely cytokinins and cytokinin-derived purine inhibitors of cyclin-dependent kinases belongs to the most intensively studied compounds. The representative of the latter, roscovitine (CYC202, seliciclib), already undergoes phase II clinical trials in patients as a novel anticancer drug held by Cyclacel Ltd (for more information see actual Press Release).
Our multidisciplinary research team is composed of experienced plant physiologists, biochemists as well as organic and analytical chemists. Many students are involved in the research during their pregradual and postgraduate studies of botany, analytical and organic chemistry, biochemistry or medicinal biology, respectively.
Laboratory of Growth Regulators guarantees the teaching for biological study programs. Members of the laboratory give lectures from general botany, plant physiology, microbiology, chemistry, molecular biology, including practical courses and seminars.
Several reseach projects are in progress in colaboration with international partners (University of Berlin, Germany; Swedish University of Agricultural Sciences, Sweden; University of Natal Pietermaritzburg, South Africa; Vienna Medical University, Austria).
head of the laboratorysenior scientist
- Prof. ing. Miroslav Strnad CSc.
- RNDr. Martin Fellner Ph.D.
- Jiří Grúz
- Doc., Ing. Jan Krekule DrSc.
- Doc. RNDr. Vladimír Kryštof Ph.D.
- RNDr. Miroslav Kvasnica Ph.D.
- doc. Mgr. Ondřej Novák Ph.D.
- Ing. Ludmila Ohnoutková Ph.D.
- Mgr. Jana Oklešťková PhD.
- Mgr. Lucie Plíhalová Ph.D.
- Jiří Pospíšil
- Jitka Široká
- Mgr. Danuše Tarkowská Ph.D.
- Jiří Voller
graduated technical assistant
- Jitka Hansgutová DiS.
5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases Record contains structuresEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 110 291-301 2016 Fulltext: public PDF link
- 33 614-624 2016
The determination of 22 natural brassinosteroids in a minute sample of plant tissue by UHPLC–ESI–MS/MSANALYTICAL AND BIOANALYTICAL CHEMISTRY 2016 (External fulltext)
Analysis of plant growth-promoting properties of Bacillus amyloliquefaciens UCMB5113 using Arabidopsis thaliana as host plantPLANTA 2016 (External fulltext)
- PLANT PHYSIOLOGY 172 874–888 2016 (External fulltext)
Comparative “Omics” of the Fusarium fujikuroi species complex highlights differences in genetic potential and metabolite synthesisGENOME BIOLOGY AND EVOLUTION 8 3574–3599 2016 (External fulltext)
- NATURE PLANTS 2 Article number: 16013 2016 (External fulltext)
Cytokinin metabolism in maize: novel evidence of cytokinin abundance, interconversions and formation of a new trans-zeatin metabolic product with a weak anticytokinin activityPLANT SCIENCE 247 127-137 2016 (External fulltext)
Putative O-linked N-acetylglucosamine transferase SPINDLY inhibits class I TCP proteolysis to promote sensitivity to cytokininPLANT PHYSIOLOGY 171 1485-1494 2016 (External fulltext)
Plant ecdysteroids: plant sterols with intriguing distributions, biological effects and relations to plant hormonesPLANTA 244 (3) 545-555 2016 (External fulltext)