Laboratory of Growth Regulators
Laboratory of Growth Regulators has been created in 1995 as a joined facility of the Faculty of Science, Palacký University (www.upol.cz) and Institute of Experimental Botany, Academy of Sciences of the Czech Republic (www.ueb.cas.cz).
Research program of the laboratory is aimed primary at small molecules that regulate cell division cycle, proliferation and growth of both plant and animal cells. Namely cytokinins and cytokinin-derived purine inhibitors of cyclin-dependent kinases belongs to the most intensively studied compounds. The representative of the latter, roscovitine (CYC202, seliciclib), already undergoes phase II clinical trials in patients as a novel anticancer drug held by Cyclacel Ltd (for more information see actual Press Release).
Our multidisciplinary research team is composed of experienced plant physiologists, biochemists as well as organic and analytical chemists. Many students are involved in the research during their pregradual and postgraduate studies of botany, analytical and organic chemistry, biochemistry or medicinal biology, respectively.
Laboratory of Growth Regulators guarantees the teaching for biological study programs. Members of the laboratory give lectures from general botany, plant physiology, microbiology, chemistry, molecular biology, including practical courses and seminars.
Several reseach projects are in progress in colaboration with international partners (University of Berlin, Germany; Swedish University of Agricultural Sciences, Sweden; University of Natal Pietermaritzburg, South Africa; Vienna Medical University, Austria).
head of the laboratorysenior scientist
- Prof. ing. Miroslav Strnad CSc.
- RNDr. Martin Fellner Ph.D.
- Jiří Grúz
- Doc., Ing. Jan Krekule DrSc.
- Doc. RNDr. Vladimír Kryštof Ph.D.
- RNDr. Miroslav Kvasnica Ph.D.
- doc. Mgr. Ondřej Novák Ph.D.
- Ing. Ludmila Ohnoutková Ph.D.
- Mgr. Jana Oklešťková PhD.
- Mgr. Lucie Plíhalová Ph.D.
- Jiří Pospíšil
- Jitka Široká
- Mgr. Danuše Tarkowská Ph.D.
- Jiří Voller
graduated technical assistant
- Jitka Hansgutová DiS.
Triazolide strigolactone mimics as potent selective germinators of parasitic plant Phelipanche ramosaPEST MANAGEMENT SCIENCE in press 2019
Quantitative Analysis of Ingenol in Euphorbia species via Validated Isotope Dilution Ultra‐high Performance Liquid Chromatography Tandem Mass SpectrometryPHYTOCHEMICAL ANALYSIS 29 23-29 2018 (External fulltext)
- PLANT JOURNAL 2018 (External fulltext)
Antibody-mediated modulation of cytokinins in tobacco: organ-specific changes in cytokinin homeostasisJOURNAL OF EXPERIMENTAL BOTANY 69 441-454 2018 Fulltext: PDF link on intranet only
- PLANTA 2018 (External fulltext)
- EUROPEAN JOURNAL OF PHYCOLOGY 2018 (External fulltext)
The novel brassinosteroid analog BR4848 inhibits angiogenesis in human endothelial cells and induces apoptosis in human cancer cells in vitroJournal of steroid biochemistry and molecular biology 178 263-271 2018
- PLANT PHYSIOLOGY 177 476-489 2018 (External fulltext)
Vacuole Integrity Maintained by DUF300 Proteins Is Required for Brassinosteroid Signaling RegulationMOLECULAR PLANT 2018 (External fulltext)
Biochemical and Physicochemical Background of Mammalian Androgen Activity in Winter Wheat Exposed to Low TemperatureJOURNAL OF PLANT GROWTH REGULATION 37 199-219 2018