Formin homology 2 domains occur in multiple contexts in angiosperms

Cvrčková, F.; Novotný, M.; Pícková, Denisa; Žárský, Viktor
BMC GENOMICS 5 [44]: 1-18, 2004

Klíčová slova: Formin; angiosperms; Arabidopsis
Abstrakt: Involvement of conservative molecular modules and cellular mechanisms in the widely diversified processes of eukaryotic cell morphogenesis leads to the intriguing question: how do similar proteins contribute to dissimilar morphogenetic outputs. Formins (FH2 proteins) play a central part in the control of actin organization and dynamics, providing a good example of evolutionarily versatile use of a conserved protein domain in the context of a variety of lineage-specific structural and signalling interactions. The plant-specific domain context of the conserved FH2 domain, as well as plant-specific features of the domain itself, may reflect distinct functional requirements in plant cells. The variability of formin structures found in plants far exceeds that known from both fungi and metazoans, suggesting a possible contribution of FH2 proteins in the evolution of the plant type of multicellularity.
Autoři z ÚEB: Viktor Žárský